Pharmaceuticals (2016)
Update date:2022-07-29
Topics:
Vasilevich, Natalya I.
Tatarskiy, Victor V.
Aksenova, Elena A.
Kazyulkin, Denis N.
Afanasyev, Ilya I.
Based on the data for compounds known from the literature to be active against various types of Ser/Thr kinases, a general pharmachophore model for these types of kinases was developed. The search for the molecules fitting to this pharmacophore among the ASINEX proprietary library revealed a number of compounds, which were tested and appeared to possess some activity against Ser/Thr kinases such as Aurora A, Aurora B and Haspin. Our work on the optimization of these molecules against Aurora A kinase allowed us to achieve several hits in a 3-5 nM range of activity with rather good selectivity and Absorption, Distribution, Metabolism, and Excretion (ADME) properties, and cytotoxicity against 16 cancer cell lines. Thus, we showed the possibility to fine-tune the general Ser/Thr pharmacophore to design active and selective compounds against desired types of kinases.
View MoreContact:0572-2722882
Address:1201,F3,xinghuibandao,
Jiangyin Tenghua Import&Export Co.,Ltd.
Contact:+86-510-86263875
Address:Room 402-B,9 Yanling Road, Jiangyin,Jiangsu, China
Anhui New Star Pharmaceutical Development Co., Ltd
Contact:013956922763
Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Contact:852-27701081
Address:Room 2509, New Tech Plaza, 34 Tai Yau St., San Po Kong, HK
Zibo Jujin Chemical Industry Co., Ltd.(Dongming Jujin Chemical Industry Co., Ltd. )
Contact:+86-533-2975022
Address:No.99 Shanquan Road, Zhangdian District
Doi:10.1039/d1gc01635k
(2021)Doi:10.1016/j.tet.2006.10.027
(2007)Doi:10.1007/s10562-019-03073-2
(2020)Doi:10.1016/0022-328X(84)80339-3
(1984)Doi:10.1016/j.tetlet.2006.11.058
(2007)Doi:10.1007/BF00899309
(1953)