An Improved One-pot Synthesis of Nα-(tert-Butoxycarbonyl)-O-(O',O"-dialkylphosphoro)-L-tyrosines Using Dialkyl N,N-Diethylphosphoramidites

Article abstract of DOI:10.1055/s-1989-27366

N^α-(tert-Butoxycarbonyl)-O-(O',O"-dialkylphosphoro)-L-tyrosines 6a-c were prepared in high yields by an efficient one-pot procedure, which involved initial tert-butyldimethylsilyl protection of the carboxy terminus of N-Boc tyrosine 1 followed