Controlled reduction of acarbose: Conformational analysis of acarbose and the resulting saturated products

Article abstract of DOI:10.1016/0008-6215(91)80045-O

Saturation of the double bond in the non-reducing terminal unit of the tetrasaccharide amylase inhibitor, acarbose (1), with Raney nickel as the catalyst and at pH 8, gave 57% of a ~1:1 mixture of the 5a-carba-gluco (2) and -ido (3) isomers together with