Chemical and Pharmaceutical Bulletin p. 1216 - 1225 (1994)
Update date:2022-08-04
Topics:
Matsuda
Kuroyanagi
Sugiyama
Umehara
Ueno
Nishi
The methanol extract of the aerial part of Andrographis paniculata NEES showed potent cell differentiation-inducing activity on mouse myeloid leukemia (MI) cells. From the ethyl acetate-soluble fraction of the methanol extract, six new diterpenoids of ent-labdane type, 14-epi-andrographolide (3), isoandrographolide (4), 14-deoxy-12-methoxyandrographolide (7), 12-epi- 14-deoxy-12-methoxyandrographolide (8), 14-deoxy-12-hydroxyandrographolide (9) and 14-deoxy-12-hydroxyandrographolide (10) as well as two new diterpene glucosides, 14-deoxy-11, 12-didehydroandrographi-side (12) and 6'- acetylneoandrographolide (14), and four new diterpene dimers, bis- andrograpolides A (15), B (16), C (17) and D (18), were isolated along with six known compounds. The structures of the diterpenoids were determined by means of spectral methods. Some of these compounds showed potent cell differentiation-inducing activity towards M1 cells.
View MoreContact:+86-(0)21-3770 9035
Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
Jinzhou Jiutai Pharmaceutical Co.,Ltd
Contact:+86-0416-5179890
Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
Nanyang Tianhua pharmaceutical Co.,Ltd.
Contact:+8618639816203
Address:Longsheng Industrial Park
Dalian Join King Biochemical Tech. Co., Ltd.
Contact:0411 39216206
Address:814 First State Blvd
Hangzhou Eastbiopharm Co.,Ltd.
Contact:+86-571-88931780
Address:Hangzhou,China
Doi:10.1039/c6ob02714h
(2017)Doi:10.1039/d0dt02937h
(2020)Doi:10.1016/S0040-4020(01)91132-9
(1984)Doi:10.1021/ja00883a064
(1962)Doi:10.3987/com-06-s(o)3
(2006)Doi:10.1016/S0040-4039(01)81316-2
(1984)
