Chemical and Pharmaceutical Bulletin p. 1216 - 1225 (1994)
Update date:2022-08-04
Topics:
Matsuda
Kuroyanagi
Sugiyama
Umehara
Ueno
Nishi
The methanol extract of the aerial part of Andrographis paniculata NEES showed potent cell differentiation-inducing activity on mouse myeloid leukemia (MI) cells. From the ethyl acetate-soluble fraction of the methanol extract, six new diterpenoids of ent-labdane type, 14-epi-andrographolide (3), isoandrographolide (4), 14-deoxy-12-methoxyandrographolide (7), 12-epi- 14-deoxy-12-methoxyandrographolide (8), 14-deoxy-12-hydroxyandrographolide (9) and 14-deoxy-12-hydroxyandrographolide (10) as well as two new diterpene glucosides, 14-deoxy-11, 12-didehydroandrographi-side (12) and 6'- acetylneoandrographolide (14), and four new diterpene dimers, bis- andrograpolides A (15), B (16), C (17) and D (18), were isolated along with six known compounds. The structures of the diterpenoids were determined by means of spectral methods. Some of these compounds showed potent cell differentiation-inducing activity towards M1 cells.
View MoreWuhan Chemchemical Co., Ltd.(expird)
Contact:15973022782
Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
Jiaxing Taixin Pharmaceutical Chemical Co., Ltd
Contact:0573-82613601
Address:Chemical Park, Jiaxing, Zhejiang, China
website:http://www.chemdow.com
Contact:0086-10-82435335
Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Tianjin Jingye Fine Chemicals Co., Ltd.
Contact:+86-15722078107; +86-22-26911407
Address:Bohua Fine Chemicals Base of Petrochemical Industry Park, Nanhuan Road, Dagang District, Tianjin, 300271, P. R. China
website:http://www.eastarchem.com/
Contact:1-800-898-2436
Address:1215 K Street, STE 1700
Doi:10.1039/c6ob02714h
(2017)Doi:10.1039/d0dt02937h
(2020)Doi:10.1016/S0040-4020(01)91132-9
(1984)Doi:10.1021/ja00883a064
(1962)Doi:10.3987/com-06-s(o)3
(2006)Doi:10.1016/S0040-4039(01)81316-2
(1984)
