Tetrahedron p. 1795 - 1802 (1984)
Update date:2022-08-04
Topics:
Shiozaki, Masao
Ishida, Noboru
Hiraoka, Tetsuo
Maruyama, Hiroshi
L-Threonine was transformed, stereospecifically, to a versatile β-lactam (5a) in 3 steps.This β-lactam was further converted to a key intermediate (25) for the synthesis of thienamycin and its biologically active analogues.Furthermore, the compound 5a was changed to iodides (18 and 23), cyanides (19 and 24), chloromethylketone (26) and aldehydes (30 and 31) which appear to have a latent potential as precursors for the syntheses of the carbapenems.
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Doi:10.1039/jr9420000368
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(1984)
