Bioorganic and Medicinal Chemistry Letters p. 1901 - 1906 (1999)
Update date:2022-08-04
Topics:
Brouillette, Wayne J.
Atigadda, Venkatram R.
Ming, Luo
Air, Gillian M.
Babu, Yarlagadda S.
Bantia, Shanta
A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3- guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.
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