Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping

DOI: 10.1016/S0960-894X(99)00318-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1901 - 1906 (1999)

Update date:2022-08-04

Topics:

Authors:

Brouillette, Wayne J.

Atigadda, Venkatram R.

Ming, Luo

Air, Gillian M.

Babu, Yarlagadda S.

Bantia, Shanta

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Article abstract of DOI:10.1016/S0960-894X(99)00318-2

A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3- guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.

Full text of DOI:10.1016/S0960-894X(99)00318-2

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