Synthesis of 4-demethoxyadriamycinone utilizing ruthenium-catalyzed oxidation of allyl acetates

DOI: 10.1016/S0040-4039(01)00428-2

Source and publish data:

Tetrahedron Letters p. 3343 - 3346 (2001)

Update date:2022-08-03

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Authors:

Hottop, Torsten

Gutke, Hans-Jürgen

Murahashi, Shun-Ichi

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Article abstract of DOI:10.1016/S0040-4039(01)00428-2

A new method for the construction of the side chain of anti-cancer drugs adriamycins is demonstrated by the synthesis of 4-demethoxyadriamycinone. The key step is the ruthenium-catalyzed oxidation of allyl acetates to the corresponding α-hydroxyketones.

Full text of DOI:10.1016/S0040-4039(01)00428-2

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