Design and synthesis of novel bis(l-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity

DOI: 10.1016/j.bmcl.2006.10.021

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Bioorganic and Medicinal Chemistry Letters p. 465 - 470 (2007)

Update date:2022-08-03

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Authors:

Fu, Xiaozhong

Jiang, Saihong

Li, Chuan

Xin, Jian

Yang, Yushe

Ji, Ruyun

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Article abstract of DOI:10.1016/j.bmcl.2006.10.021

A series of novel bis(l-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl] adenine (PMEA) was synthesized and their anti-HBV activity was evaluated in HepG 2 2.2.15 cells. Compounds 11, 12, 21, 22, 26, and 27 demonstrated more potent anti-HBV act

Full text of DOI:10.1016/j.bmcl.2006.10.021

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Product name:2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-{[2-(6-amino-purin-9-yl)-ethoxymethyl]-[2-(2-tert-butoxycarbonylamino-3-phenyl-propionyloxy)-ethoxy]-phosphinoyloxy}-ethyl ester

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