
Journal of Organic Chemistry p. 1315 - 1325 (2007)
Update date:2022-08-04
Topics: Imines Asymmetric reduction Organocatalysis Fluorous tag Trichlorosilane
Malkov, Andrei V.
Figlus, Marek
Stoncius, Sigitas
Kocovsky, Pavel
(Chemical Equation Presented) Asymmetric reduction of ketimines 1 with trichlorosilane can be catalyzed by N-methylvaline-derived Lewis-basic formamides 3a-d with high enantioselectivity (≤95% ee) and low catalyst loading (1-5 mol %) at room temperature i
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