GENERAL SYNTHETIC ACCESS TO α-ALLENYL AMINES AND α-ALLENYL-α-AMINOACIDS AS POTENTIAL ENZYME ACTIVATED IRREVERSIBLE INHIBITORS OF PLP DEPENDENT ENZYMES

Article abstract of DOI:10.1016/S0040-4039(01)90068-1

The entitled allene derivatives have been prepared from the parent α-ethynyl amines and α-amino acids.The corresponding derivative of GABA, putrescine and phenylalanine have been found to be irreversible and time dependent inhibitors of GABA-T, ODC and ba