Angewandte Chemie - International Edition p. 591 - 597 (2007)
Update date:2022-07-30
Topics: Yield NMR spectroscopy Catalyst Stereochemistry Chromatography Total synthesis Chemical Reaction Rapamycin
Maddess, Matthew L.
Tackett, Miles N.
Watanabe, Hidenori
Brennan, Paul E.
Spilling, Christopher D.
Scott, James S.
Osborn, David P.
Ley, Steven V.
Rapamycin synthesis all wrapped up: A new convergent synthesis of rapamycin (1) is reported that involves a macroetherification/catechol tethering strategy for construction of the macrocyclic core of this intriguing natural product. Other studies on this commercialized potent immunosuppressant delineate new cell signaling pathways of relevance to cancer chemotherapy. (Chemical Equation Presented).
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