Highly diastereoselective preparation of (E)-alkenylsilanes bearing an α-chiral center

Article abstract of DOI:10.1021/ol063097o

(Chemical Equation Presented) The copper(I)-mediated anti-S _N2′ allylic substitution allows a highly stereoselective preparation of alkenylsilanes bearing a chiral center in the α-position with high transfer of chirality. These alkenylsilanes were converted into α,β-unsaturated ketones or into the corresponding boronic esters without loss of the chiral information.