Synthesis of α-phosphorylated α,β-unsaturated imines and their selective reduction to vinylogous and saturated α-aminophosphonates

Article abstract of DOI:10.1021/jo062609+

An efficient synthesis of α,β-unsaturated imines derived from α-aminophosphonates is achieved through aza-Wittig reaction of P-trimethyl phosphazenes with β,γ-unsaturated α-ketophosphonates. Selective 1,2-reduction of such 1-azadienes affords β,γ-unsatura