
Journal of Organic Chemistry p. 5164 - 5174 (1984)
Update date:2022-08-04
Topics:
Rebek, Julius
Shaber, Steven H.
Shue, Youe-Kong
Gehret, Jean-Claude
Zimmerman, Stephen
The total synthesis of a mitosene (a chemical degradation product of mitomycin C) is described.The synthesis begins with hydroxyproline and uses a Huisgen pyrrole synthesis to form a pyrrolizidine system.The carbocyclic ring is made through Dieckmann cycl
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Doi:10.1021/om0611296
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