A highly regioselective synthesis of α,α-bis-Mannich bases by aminomethylation of imines with iminium salts

DOI: 10.1016/S0040-4039(99)01296-4

Source and publish data:

Tetrahedron Letters p. 6205 - 6206 (1999)

Update date:2022-08-03

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Authors:

Arend, Michael

Risch, Nikolaus

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Article abstract of DOI:10.1016/S0040-4039(99)01296-4

The aminomethylation of imines R(CH₃)C=NPr (R = alkyl, aryl) with iminium salts provides for the first time a mild, broadly applicable and highly regioselective route to bis-Mannich bases RCOCH(CH₂NR'₂)₂.

Full text of DOI:10.1016/S0040-4039(99)01296-4

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