A highly regioselective synthesis of α,α-bis-Mannich bases by aminomethylation of imines with iminium salts

DOI: 10.1016/S0040-4039(99)01296-4

Source and publish data:

Tetrahedron Letters p. 6205 - 6206 (1999)

Update date:2022-08-03

Topics:

Authors:

Arend, Michael

Risch, Nikolaus

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(99)01296-4

The aminomethylation of imines R(CH₃)C=NPr (R = alkyl, aryl) with iminium salts provides for the first time a mild, broadly applicable and highly regioselective route to bis-Mannich bases RCOCH(CH₂NR'₂)₂.

Full text of DOI:10.1016/S0040-4039(99)01296-4

Products guided by the article

Product name:3-(dimethylamino)-2-[(dimethylamino)methyl]-1-phenylpropan-1-one

Cas No:93761-96-7

R&D Labs maybe for 93761-96-7

Cartoon Ingredients Co., Ltd

website:http://www.cartoonchem.com/

Contact:+86-25-58074918

Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China
Shanxi Sanwei Group Co.,Ltd

Contact:0086-357-6662688

Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
Wuhan Chemwish Technology Co., Ltd

website:http://www.chemwish.com/

Contact:+86-27-67849912

Address:Room 1311, Unit 2, Block1, Innovation Road East Lake High-tech Development Zone Wuhan, Hubei，P.R. China
Tangshan Wisdom Trading Co.,Ltd

Contact:86 315 2222979

Address:No.41 BeiXinXi Road, Yangguang building 1-1102 , Tangshan, Hebei, China
NanJing Rate Biochemicals CO., LTD

Contact:+86-25-84931986

Address:NO. 1 Hongjing Road,Jiangning Science Park,Nanjing,China

Relevant to this article

Novel Synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate

Doi:10.3390/molecules17055604
(2012)
CYCLIC ENEDIOL PHOSPHORANES OBTAINED FROM THE REACTION OF TRIMETHYL PHOSPHITE WITH BIACETYL AND HEXAFLUOROBIACETYL GIVE STRIKINGLY DIFFERENT ACYLATION PRODUCTS

Doi:10.1016/S0040-4020(01)91291-8
(1984)
Axially chiral BINIM and Ni(II)-catalyzed highly enantioselective 1,3-dipolar cycloaddition reactions of azomethine ylides and N-arylmaleimides

Doi:10.1021/jo701561d
(2008)
Copper-Catalyzed Regioselective C-H Sulfonyloxylation of Electron-Rich Arenes with p-Toluenesulfonic Acid and Sulfonyloxylation of Aryl(mesityl)iodonium Sulfonates

Doi:10.1021/acs.joc.7b00081
(2017)
Thiazolobenzyne: A versatile intermediate for multisubstituted benzothiazoles

Doi:10.1039/c6cc05112j
(2016)
ⁿBu₄NI-catalyzed direct amination of benzoxazoles with tertiary amines using TBHP as oxidant under microwave irradiation

Doi:10.1515/znb-2015-0212
(2016)

Article Doi