A highly regioselective synthesis of α,α-bis-Mannich bases by aminomethylation of imines with iminium salts

DOI: 10.1016/S0040-4039(99)01296-4

Source and publish data:

Tetrahedron Letters p. 6205 - 6206 (1999)

Update date:2022-08-03

Topics:

Authors:

Arend, Michael

Risch, Nikolaus

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(99)01296-4

The aminomethylation of imines R(CH₃)C=NPr (R = alkyl, aryl) with iminium salts provides for the first time a mild, broadly applicable and highly regioselective route to bis-Mannich bases RCOCH(CH₂NR'₂)₂.

Full text of DOI:10.1016/S0040-4039(99)01296-4

Products guided by the article

Product name:3-(dimethylamino)-2-[(dimethylamino)methyl]-1-phenylpropan-1-one

Cas No:93761-96-7

R&D Labs maybe for 93761-96-7

Phytomarker Ltd.(expird)

Contact:+86-22-26358246

Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
shanghai jinshan pharmaceutical Co.,Ltd

Contact:021-57363011，13681638167

Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Xi'an Unique Electronic and Chemical Co., Ltd.

Contact:+86-029-88238008

Address:1703# B BUILDING WEST ELECTRONIC ZONE, XI'AN, CHINA
Hebei Kangtai Pharmaceutical Co.,Ltd

Contact:+86-0317-3512963

Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China
New Forms

Contact:+31-24-3886056

Address:Binderskampweg 29 Unit 36

Relevant to this article

Novel Synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate

Doi:10.3390/molecules17055604
(2012)
CYCLIC ENEDIOL PHOSPHORANES OBTAINED FROM THE REACTION OF TRIMETHYL PHOSPHITE WITH BIACETYL AND HEXAFLUOROBIACETYL GIVE STRIKINGLY DIFFERENT ACYLATION PRODUCTS

Doi:10.1016/S0040-4020(01)91291-8
(1984)
Axially chiral BINIM and Ni(II)-catalyzed highly enantioselective 1,3-dipolar cycloaddition reactions of azomethine ylides and N-arylmaleimides

Doi:10.1021/jo701561d
(2008)
Copper-Catalyzed Regioselective C-H Sulfonyloxylation of Electron-Rich Arenes with p-Toluenesulfonic Acid and Sulfonyloxylation of Aryl(mesityl)iodonium Sulfonates

Doi:10.1021/acs.joc.7b00081
(2017)
Thiazolobenzyne: A versatile intermediate for multisubstituted benzothiazoles

Doi:10.1039/c6cc05112j
(2016)
ⁿBu₄NI-catalyzed direct amination of benzoxazoles with tertiary amines using TBHP as oxidant under microwave irradiation

Doi:10.1515/znb-2015-0212
(2016)

Article Doi