A highly regioselective synthesis of α,α-bis-Mannich bases by aminomethylation of imines with iminium salts

Article abstract of DOI:10.1016/S0040-4039(99)01296-4

The aminomethylation of imines R(CH₃)C=NPr (R = alkyl, aryl) with iminium salts provides for the first time a mild, broadly applicable and highly regioselective route to bis-Mannich bases RCOCH(CH₂NR'₂)₂.