Synthesis of Functionalized Hydroxyphthalides and Their Conversion to 3-Cyano-1(3H)-isobenzofuranones. The Diels-Alder Reaction of Methyl 4,4-Diethoxybutynoate and Cyclohexadienes

DOI: 10.1021/jo00206a016

Source and publish data:

Journal of Organic Chemistry p. 805 - 810 (1985)

Update date:2022-08-05

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Authors:

Freskos, John N.

Morrow, Gary W.

Swenton, John S.

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Article abstract of DOI:10.1021/jo00206a016

Several methods have been used in the preparation of functionalized hydroxyphthalides.Metalation of N,N-diethyl-3-methoxybenzamide, followed by reaction with dimethylformamide and hydrolysis, furnished 3-hydroxy-4-methoxy-1(3H)-isobenzofuranone in 52perce

Full text of DOI:10.1021/jo00206a016

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