Synthesis of Functionalized Hydroxyphthalides and Their Conversion to 3-Cyano-1(3H)-isobenzofuranones. The Diels-Alder Reaction of Methyl 4,4-Diethoxybutynoate and Cyclohexadienes

DOI: 10.1021/jo00206a016

Source and publish data:

Journal of Organic Chemistry p. 805 - 810 (1985)

Update date:2022-08-05

Topics:

Authors:

Freskos, John N.

Morrow, Gary W.

Swenton, John S.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00206a016

Several methods have been used in the preparation of functionalized hydroxyphthalides.Metalation of N,N-diethyl-3-methoxybenzamide, followed by reaction with dimethylformamide and hydrolysis, furnished 3-hydroxy-4-methoxy-1(3H)-isobenzofuranone in 52perce

Full text of DOI:10.1021/jo00206a016

Products guided by the article

Product name:Benzoic acid, 2-(diethoxymethyl)-6-ethoxy-4-[(trimethylsilyl)oxy]-, methyl ester

Cas No:93832-31-6

R&D Labs maybe for 93832-31-6

NINGBO PANGS CHEM INT’L CO., LTD.

Contact:+86-0574-27666801

Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
Buffett (China) Holding Co.,Ltd

Contact:4006570891

Address:
Tangshan Wisdom Trading Co.,Ltd

Contact:86 315 2222979

Address:No.41 BeiXinXi Road, Yangguang building 1-1102 , Tangshan, Hebei, China
ShanDong XinDa Chemical CO.,LTD(expird)

Contact:086-0311-87580543

Address:No.168, High Technology Development Zone Jinan Shandong China
Nanjing Fayekong Chemcial Co.,Ltd(expird)

Contact:86-25-58813444

Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China

Relevant to this article

Free radical-mediated aryl amination: A practical synthesis of (R)- and (S)-7-azaindoline α-amino acid

Doi:10.1055/s-2004-831226
(2005)
Remarkably stable tetrahedral intermediates: Carbinols from nucleophilic additions to N-acylpyrroles

Doi:10.1002/1521-3773(20020902)41:17<3188::AID-ANIE3188>3.0.CO;2-H
(2002)
Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains

Doi:10.1016/j.ejmech.2019.05.011
(2019)
Development of an efficient and straightforward methodology toward the synthesis of molecularly diverse 2,6-disubstituted 3,4-dihydropyrimidin-4(3H)-ones

Doi:10.1055/s-2002-33924
(2002)
Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors

Doi:10.1111/cbdd.13077
(2018)
Doi:10.1021/ja01000a056
(1967)

Article Doi