Design, Synthesis, and Evaluation of Novel 2,6-Disubstituted Phenol Derivatives as General Anesthetics

DOI: 10.1021/acs.jmedchem.7b00254

Source and publish data:

Journal of Medicinal Chemistry p. 3606 - 3617 (2017)

Update date:2022-08-05

Topics:

Authors:

Qin, Linlin

Ren, Lei

Wan, Songlin

Liu, Guoliang

Luo, Xinfeng

Liu, Zhenhong

Li, Fangqiong

Yu, Yan Yu, Yan

Liu, Jianyu

Wei, Yonggang

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Article abstract of DOI:10.1021/acs.jmedchem.7b00254

A novel series of optically active 2,6-disubstituted alkylphenols with improved anesthetic profiles compared to widely used propofol were synthesized. The incorporation of the cyclopropyl group not only increased the steric effect but also introduced ster

Full text of DOI:10.1021/acs.jmedchem.7b00254

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