Chemical and Pharmaceutical Bulletin p. 3373 - 3377 (1984)
Update date:2022-08-03
Topics:
Watanabe
Kawada
Takamoto
et al.
5-Acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one (3a, AG-629), previously found to be the most potent antiulcer compound in a series of spirocyclopropanes, was obtained by one step synthesis starting from methyl 5-acetyl-2-[(tetrahydro-2-oxo-3-furanyl)oxy]benzoate (1a). In this reaction, 5,10'-(diacetyl-5',6'-dihydrospiro[benzofuran-2(3H),4'(3'H)-[2H]oxocino[3, 2-b]-benzofuran]-3-one (5a), which has a new ring system, and 1H,3H-8-acetyl-4,5-dihydro-naphtho[1,2-c:4,3-b']difuran-1-one (6) were isolated as by-products. A possible reaction mechanism is presented.
View MoreJi'nan Orgachem Pharmaceutical Co.,Ltd
Contact:+86-531-82687810
Address:Jinan
Jiangsu Fengshan Group Co., Ltd.
Contact:86-25-86558671
Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
Contact:86-28-61993785
Address:No.70-13-21, North Section, Erhuan
Contact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Contact:+86-519-86623222
Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Doi:10.1002/jps.2600520707
(1963)Doi:10.1134/S1070428006100253
(2006)Doi:10.1039/b707772f
(2007)Doi:10.1016/S0040-4020(01)91508-X
(1984)Doi:10.1016/j.tetasy.2007.06.009
(2007)Doi:10.1021/ja00294a048
(1985)
