Structure-Activity Relationship of Estrogens: Receptor Affinity and Estrogen Antagonist Activity of Certain (E)- and (Z)-1,2,3-Triaryl-2-propen-1-ones

Article abstract of DOI:10.1021/jm00382a019

(E)- nad (Z)-1,2,3-triphenyl-2-propen-1-ones and some of their phenolic and alkoxy analogues, substituted at the para position in one or more aromatic rings, were synthesized and assigned geometry on the basis on their spectroscopic data.The structure-act