New ion-exchange cum separation technique: A study for the synthesis of ω-guanidine containing peptides using ω-amino acid as surrogate

Article abstract of DOI:10.1080/00908320701230117

This article describes a systematic study for the introduction of ω-guanidine function at a late stage of synthesis using a protected amino group as a surrogate to improve overall yield. This concept was used to design and synthesize pseudo-peptides as GP IIb-IIIa receptor antagonist wherein glycine in endogenous ligand Arg-Gly-Asp (RGD) is replaced by 2-amino-thiazole-4-ylacetic acid (Tha) as a spacer. Further, we describe here a unique salt exchange cum purification technology based on reverse phase (RP-18) medium-pressure liquid chromatography. Copyright Taylor & Francis Group, LLC.