Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase

Article abstract of DOI:10.1021/jm0611657

Thiosemicarbazones of the microbial metabolite madurahydroxylactone, a polysubstituted benzo[a]-naphthacenequinone, have been previously reported by us as potent nonsteroidal inhibitors of the enzyme estrone sulfatase (cyclohexylthiosemicarbazone 1, IC