Synthesis and biological evaluation of genistein-O-alkylamine derivatives as potential multifunctional anti-Alzheimer agents

DOI: 10.1111/cbdd.13414

Source and publish data:

Chemical Biology and Drug Design p. 188 - 200 (2019)

Update date:2022-08-03

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Authors:

Hong, Chen

Guo, Hui-yan

Chen, Shuai

Lv, Jian-wu

Zhang, Xin

Yang, Ya-cheng

Huang, Kang

Zhang, Yi-juan

Tian, Zhi-yong

Luo, Wen

Chen, Yi-ping

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Article abstract of DOI:10.1111/cbdd.13414

A series of genistein derivatives were synthesized and evaluated as multifunctional anti-Alzheimer agents. The results showed that these derivatives had significant acetylcholinesterase (AChE) inhibitory activity; compound 5a exhibited the strongest inhib

Full text of DOI:10.1111/cbdd.13414

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