Copper-Catalyzed Regioselective Borylfluoromethylation of Alkenes

DOI: 10.1021/acscatal.9b01530

Source and publish data:

ACS Catalysis p. 5726 - 5731 (2019)

Update date:2022-08-03

Topics:

Authors:

Wu, Nuo-Yi

Xu, Xiu-Hua

Qing, Feng-Ling

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Article abstract of DOI:10.1021/acscatal.9b01530

A copper-catalyzed borylfluoromethylation of alkenes with fluoromethyl iodide and diboron reagents was disclosed. This protocol afforded the previously unknown and synthetically useful borylfluoromethylated alkanes in good yields and excellent regioselectivity. Its synthetic application was illustrated through the derivatization of organoboron products and preparation of monofluorinated ibuprofen.

Full text of DOI:10.1021/acscatal.9b01530

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