Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates

DOI: 10.1021/ja028459b

Source and publish data:

Journal of the American Chemical Society p. 3471 - 3485 (2003)

Update date:2022-08-04

Topics:

Authors:

Bando, Toshikazu

Narita, Akihiko

Saito, Isao

Sugiyama, Hiroshi

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Article abstract of DOI:10.1021/ja028459b

We have developed a novel type of DNA interstrand cross-linking agent by synthesizing dimers of a pyrrole (Py)/imidazole (Im)-diamide-CPI conjugate, ImPyLDu86 (1), connected using seven different linkers. The tetramethylene linker compound, 7b, efficientl

Full text of DOI:10.1021/ja028459b

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