
Tetrahedron Letters p. 4825 - 4828 (1984)
Update date:2022-08-05
Topics:
Ramage, Robert
Ashton, Christopher P.
Hopton, David
Parrott, Maxwell J.
The potential application of 1-oxo-1-chlorophospholane (5) as a novel reagent for the in situ activation of N α-protected amino acids for use in peptide bond forming reactions has been examined.Wherever possible, 32.4 MHz 31P nuclear magnetic resonance (n.m.r.) spectroscopy was employed to follow both the formation of the intermediate phospholanic-carboxylic mixed anhydride and the subsequent aminolysis reaction.
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