Bioorganic and Medicinal Chemistry p. 5046 - 5052 (2012)
Update date:2022-07-29
Topics:
Fioravanti, Rossella
Celestino, Ignacio
Costi, Roberta
Cuzzucoli Crucitti, Giuliana
Pescatori, Luca
Mattiello, Leonardo
Novellino, Ettore
Checconi, Paola
Palamara, Anna Teresa
Nencioni, Lucia
Santo, Roberto Di
A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
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Doi:10.1002/mrc.2087
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