Design and Synthesis of Mannose Analogues as Inhibitors of α-Mannosidase

Article abstract of DOI:10.1016/S0040-4020(01)81349-1

A series of N-, C- and S- mannopyranosyl derivatives (4, 9-16) have been synthesised and their inhibitory activity tested towards jackbean α-mannosidase (EC 3.2.1.24).These compounds are of mechanistic and synthetic interest in the design of new α-mannosidase inhibitors.