Direct synthesis of thiols from halides and epoxides using hydrosulfide exchange resin in methanol

Article abstract of DOI:10.1055/s-1995-3929

Various thiols are prepared directly from the corresponding alkyl halides and epoxides using hydrosulfide exchange resin in methanol in the presence of equimolar amounts of triethylammonium chloride at room temperature. The reaction not only proceeds with unique chemoselectivity, but also gives better yields of thiols than most commonly used indirect methods and has an additional advantage of a simple workup.