Resolution and stereoselective synthesis of the herpes thymidine kinase inhibitor L-653180

Article abstract of DOI:10.1016/S0957-4166(97)00019-0

Resolution of L-653180, (±)-9-{[(Z)-2-(hydroxymethyl)cyclohexyl]-methyl}guanine, a racemic, nonsubstrate inhibitor of HSV-TK, was achieved and the absolute stereochemistry of the enantiomers was determined. Enzyme inhibition was shown to reside in the ena