Use of Enzymatic Hydrolysis of Dimethyl Malates for a Short Synthesis of Tulipalin B and of Its Enantiomer

Article abstract of DOI:10.1021/jo00207a054

Pig liver esterase (PLE) hydrolyzes the ester function α to the hydroxyl group in dimethyl malate.This regiospecific reaction was used to synthesize (+)- and (-)-tulipalin B.