Total synthesis of 3,3′,4-tri-O-methylellagic acid from gallic acid

Article abstract of DOI:10.1016/j.tet.2007.07.103

Total synthesis of 3,3′,4-tri-O-methylellagic acid has been described from commercially available gallic acid. Construction of the crucial unsymmetric Ar-Ar bond has been carried out in various methods such as Heck coupling, Heck coupling followed by oxidation or anionic Fries rearrangement, Suzuki cross-coupling, etc., but all the attempts were unsuccessful. Then, finally it has been achieved by intramolecular Ullmann coupling reaction.