A NEW METHOD FOR NUCLEOPHILIC OXYMETHYLATION USING α-ALKOXYSILANES. SYNTHESIS OF UNSYMMETRICAL 1,2-DIOLS

DOI: 10.1246/cl.1984.1803

Source and publish data:

Chemistry Letters p. 1803 - 1806 (1984)

Update date:2022-08-02

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Authors:

Tsuge, Otohiko

Kanemasa, Shuji

Nagahama, Hideki

Tanaka, Junji

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Article abstract of DOI:10.1246/cl.1984.1803

Desilylation of α-alkoxysilanes offers the convenient generation of carbinyl carbanions which react with a variety of carbonyl compounds giving mono-protected 1,2-diols of unsymmetrical type.Dehydration of these unsymmetrical diols leads to the regioselective formation of methyl ketones.

Full text of DOI:10.1246/cl.1984.1803

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