Synthesis and pharmacological properties of pyrazolotriazolopyrimidine derivatives

DOI: 10.1016/0223-5234(92)90064-8

Source and publish data:

European Journal of Medicinal Chemistry p. 73 - 80 (1992)

Update date:2022-08-05

Topics: Synthesis Melting point Antimicrobial activity Bioassay Derivatives Chromatography Recrystallization Mass spectrometry (MS) IC50 Solubility TLC (thin-layer chromatography) HPLC (high-performance liquid chromatography) NMR (nuclear magnetic resonance) Purification In vitro Testing In Vivo Testing Docking Studies Pharmacokinetics Toxicity Pharmacological Properties Anticancer activity Spectroscopic Analysis Heterocyclic compound SAR (Structure-Activity Relationship) Reaction yield

Authors:

Russo, F

Guccione, S

Romeo, G

Monsu'Scolaro, L

Pucci, S

et al. et al.

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Article abstract of DOI:10.1016/0223-5234(92)90064-8

As a part of research on anti-inflammatory-analgesic compounds, pyrazolotriazolopyrimidines were prepared by cycling the corresponding 2-phenylamino-3-aminopyrazolo<3,4-d>pyrimidin-4-one derivatives 3a-h with triethylorthoformate, in the presence of p-tol

Full text of DOI:10.1016/0223-5234(92)90064-8

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