European Journal of Medicinal Chemistry p. 73 - 80 (1992)
Update date:2022-08-05
Topics: Synthesis Melting point Antimicrobial activity Bioassay Derivatives Chromatography Recrystallization Mass spectrometry (MS) IC50 Solubility TLC (thin-layer chromatography) HPLC (high-performance liquid chromatography) NMR (nuclear magnetic resonance) Purification In vitro Testing In Vivo Testing Docking Studies Pharmacokinetics Toxicity Pharmacological Properties Anticancer activity Spectroscopic Analysis Heterocyclic compound SAR (Structure-Activity Relationship) Reaction yield
Russo, F
Guccione, S
Romeo, G
Monsu'Scolaro, L
Pucci, S
et al.
As a part of research on anti-inflammatory-analgesic compounds, pyrazolotriazolopyrimidines were prepared by cycling the corresponding 2-phenylamino-3-aminopyrazolo<3,4-d>pyrimidin-4-one derivatives 3a-h with triethylorthoformate, in the presence of p-tol
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