Two new methods to form substituted oligoethylene glycols

Article abstract of DOI:10.1016/S0040-4039(00)76642-1

1-Bromo-2-trityloxyethane (1) and 1-allyloxymethyl-2-trityloxyethanol (2) react readily at room temperature with substituted oligoethylene glycols or the ditosylate derivative of an oligoethylene glycol, respectively, to form the extended, ditrityl-protected, substituted oligoethylene glycols in high yields. The trityl groups are easily removed by acidified methanol in CH₂Cl₂ to give the extended, substituted oligoethylene glycols.