Journal of Medicinal Chemistry p. 958 - 960 (1985)
Update date:2022-08-04
Topics:
Kaneko, T.
Wong, H.
Howell, H. G.
Rose, W. C.
Bradner, W. T.
Doyle, T. W.
Amine-containing trichothecanes were prepared by reductive aminations of 3-ketoanguidin.In in vivo tests against P388 leukemia, most of them showed an improved activity compared to anguidin though their potency was decreased. 3-Ketoanguidin also produced some unexpected structures: oxazoline 5, dioxaline 7, and α-amino nitrile 13.
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(1985)
