Synthesis of 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-5-benzyluracil and its amino analogue, new potent uridine phosphorylase inhibitors with high water solubility

DOI: 10.1021/jm00145a023

Source and publish data:

Journal of Medicinal Chemistry p. 971 - 973 (1985)

Update date:2022-08-03

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Authors:

Tai-Shun Lin

Mao-Chin Liu

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Article abstract of DOI:10.1021/jm00145a023

Acyclic nucleosides 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-5-benzyluracil (DHPBU) (1) and 1-[[2-hydroxy-1-(aminomethyl)ethoxy]methyl]-5-benzyluracil (AHPBU) (2) have been synthesized by direct coupling of bis(trimethylsilyl)-5-benzyluracil with the

Full text of DOI:10.1021/jm00145a023

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Product name:1-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>-methyl>-5-benzyluracil

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