Acetoacetylation with 2,2,6-Trimethyl-4H-1,3-dioxin-4-one: A Convenient Alternative to Diketene.

DOI: 10.1021/jo00214a006

Source and publish data:

Journal of Organic Chemistry p. 2431 - 2435 (1985)

Update date:2022-07-29

Topics:

Authors:

Clemens, Robert J.

Hyatt, John A.

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Article abstract of DOI:10.1021/jo00214a006

The diketene/acetone adduct, 2,2,6-trimethyl-4H-1,3-dioxin-4-one, efficiently acetoacetylates aliphatic and aromatic alcohols, amines, and thiols.These acetoacetylation reactions are fast and stoichiometric, require no catalysis, and give only volatile byproducts.

Full text of DOI:10.1021/jo00214a006

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