Journal of Medicinal Chemistry p. 1054 - 1062 (1985)
Update date:2022-08-04
Topics:
Stillings, Michael R.
Chapleo, Christopher B.
Butler, Richard C. M.
Davis, J. Alfred
England, C. David
et al.
The synthesis and pharmacological activity of a series of 2-substituted derivatives of the selective α2-adrenoreceptor antagonist idazoxan (RX 781094) is described.Substitution in this position by alkyl, alkenyl, cycloalkenyl, and alkoxy groups in many cases gives compounds whose potencies and selectivities are significantly greater than those of the parent compound.
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(2021)
