Nitropyridyl glycosides: New glycosyl donors for enzymatic transglycosylation

Article abstract of DOI:10.1016/S0040-4039(99)01279-4

New glycosyl donors, 3-nitro-2-pyridyl and 5-nitro-2-pyridyl glycosides, proved to be effective for transglycosylation reaction catalyzed by glycosidases, such as β-galactosidase, β-glucosidase, and N-acetyl-β- hexosaminidase. The high solubility in water and the high reactivity of the nitropyridyl glycosides enabled the reactions under high concentrations of the donors and consequently rapid glycosyl transfer to glycosyl acceptors. The yields of the transglycosylated products with the nitropyridyl glycosides were much higher than those with conventional p-nitrophenyl glycosides.