Synthesis an Biological Effects of Novel Thiocolchicines. 3. Evaluation of N-Acyldeacetylthiocolchicines, N-(Alkoxycarbonyl)deacetylthiocolchicines, and O-Ethyldemethylthiocolchicines. New Synthesis of Thiodemecolcine and Antileukemic Effects of 2-Demethy

DOI: 10.1021/jm00147a014

Source and publish data:

Journal of Medicinal Chemistry p. 1204 - 1208 (1985)

Update date:2022-08-04

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Authors:

Kerekes, Peter

Sharma, Padam N.

Brossi, Arnold

Chignell, Colin F.

Quinn, Frank R.

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Article abstract of DOI:10.1021/jm00147a014

Novel and known analogues of thiocolchicine were evaluated in a tubulin binding assay in vivo in mice for acute toxicity and in the P338 lymphocytic leukemia assay.This evaluation included N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl)deacetylthiocolch

Full text of DOI:10.1021/jm00147a014

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