Stereoselective synthesis of a trans-octahydroindole derivative, precursor of trandolapril (RU 44 570), an inhibitor of angiotensin converting enzyme

DOI: 10.1016/S0040-4039(00)61225-X

Source and publish data:

Tetrahedron Letters p. 4889 - 4892 (1992)

Update date:2022-07-31

Topics:

Authors:

Brion Brion

Marie Marie

Mackiewicz

Roui Roui

Buendia Buendia

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Article abstract of DOI:10.1016/S0040-4039(00)61225-X

We describe a stereoselective synthesis of the trans-octahydroindole-2-carboxylic acid 2 a key intermediate in the elaboration of Trandolapril (RU 44 570) 1. The optically active starting material used was obtained by an enzymatic hydrolysis.

Full text of DOI:10.1016/S0040-4039(00)61225-X

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