Stereoselective synthesis of a trans-octahydroindole derivative, precursor of trandolapril (RU 44 570), an inhibitor of angiotensin converting enzyme

Article abstract of DOI:10.1016/S0040-4039(00)61225-X

We describe a stereoselective synthesis of the trans-octahydroindole-2-carboxylic acid 2 a key intermediate in the elaboration of Trandolapril (RU 44 570) 1. The optically active starting material used was obtained by an enzymatic hydrolysis.