Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain

DOI: 10.1021/jm00155a012

Source and publish data:

Journal of Medicinal Chemistry p. 655 - 660 (1986)

Update date:2022-07-29

Topics: In vitro   Analogue   Methotrexate   Aminopterin   Dihydrofolate reductase   folylpolyglutamate synthetase  

Authors:

Rosowsky

Freisheim

Moran

Solan

Bader

Wright

Radike-Smith