AN EFFICIENT METHOD FOR SELECTIVE AMINO ACID PROTECTION OF meso-2,2'-DIAMINODICARBOXYLIC ACID: AN IMPROVED SYNTHESIS OF FK-156

DOI: 10.1016/S0040-4039(00)86924-5

Source and publish data:

Tetrahedron Letters p. 693 - 696 (1982)

Update date:2022-08-04

Topics:

Authors:

Hemmi, Keiji

Takeno, Hidekazu

Okada, Satoshi

Nakaguchi, Osamu

Kitaura, Yoshihiko

Hashimota, Masashi

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Article abstract of DOI:10.1016/S0040-4039(00)86924-5

An efficient method for selective amino acid protection with proper differentiation between the two amino acid groups in meso-2,2'-diaminopimelic acid has been achieved (7 -> 8 -> 9 -> 10 -> 11) and applied to the synthesis of FK-156 (10 -> 12 -> 14 -> 1)

Full text of DOI:10.1016/S0040-4039(00)86924-5

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