Journal of Medicinal Chemistry p. 2114 - 2121 (1990)
Update date:2022-08-04
Topics:
Brown
Kinnick
Morin Jr.
Vasileff
Counter
Davidson
Ensminger
Eudaly
Kasher
Katner
Koehler
Kurz
Lindstrom
Lunn
Preston
Ott
Quay
Shadle
Steinberg
et al.
The preparation and biological evaluation of a series of 7β-[2-(2-aminothiazol-4-yl)-2(Z)-methoximinoacetamido]cephalosporins, substituted at the 3'-position with monocyclic or bicyclic nitrogen-containing heterocycles are described. The resulting family of parenteral compounds displays a broad spectrum of antibacterial activity. Some compounds exhibit a similar level of Gram-negative activity to that of the 'third-generation' cephalosporins with increased staphylococcal activity. The in vitro and in vivo antimicrobial activity, structure-activity relationships, β-lactamase stability, and in vitro and in vivo pharmacological evaluations are presented.
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Doi:10.1248/cpb.33.2287
(1985)Doi:10.1007/BF01518281
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(1992)Doi:10.1007/BF00807099
(1997)Doi:10.1002/hlca.19850680310
(1985)Doi:10.1002/ardp.19873200115
(1987)