Journal of Medicinal Chemistry p. 2114 - 2121 (1990)
Update date:2022-08-04
Topics:
Brown
Kinnick
Morin Jr.
Vasileff
Counter
Davidson
Ensminger
Eudaly
Kasher
Katner
Koehler
Kurz
Lindstrom
Lunn
Preston
Ott
Quay
Shadle
Steinberg
et al.
The preparation and biological evaluation of a series of 7β-[2-(2-aminothiazol-4-yl)-2(Z)-methoximinoacetamido]cephalosporins, substituted at the 3'-position with monocyclic or bicyclic nitrogen-containing heterocycles are described. The resulting family of parenteral compounds displays a broad spectrum of antibacterial activity. Some compounds exhibit a similar level of Gram-negative activity to that of the 'third-generation' cephalosporins with increased staphylococcal activity. The in vitro and in vivo antimicrobial activity, structure-activity relationships, β-lactamase stability, and in vitro and in vivo pharmacological evaluations are presented.
View MoreContact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
website:http://www.trustwe.com
Contact:+86-21-61551611
Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong
WUXI HONOR SHINE CHEMICAL CO.,LTD
Contact:+86-510-83593312
Address:No.1699 Huishan avenue,Huishan district,Wuxi ,Jiangsu,China,214177.(Wuxi Huishan Ecomonic Develop Zone )
Hefei Highzone Fine Chemical S&T CO.,LTD
Contact:86-0551-63663560
Address:room 1801 NO. 24 Shuguang RD.
Jinan Boss Chemical Industry Co., Ltd.
website:http://www.chemboss.com.cn
Contact:+86-531-58591595
Address:No2.Hualong Road, Jinan, China
Doi:10.1248/cpb.33.2287
(1985)Doi:10.1007/BF01518281
(1916)Doi:10.1016/S0040-4039(00)91596-X
(1992)Doi:10.1007/BF00807099
(1997)Doi:10.1002/hlca.19850680310
(1985)Doi:10.1002/ardp.19873200115
(1987)