A general and accurate nmr determination of the enantiomeric purity of α-aminoacids and α-aminoacid derivatives

Article abstract of DOI:10.1016/S0040-4020(01)86812-5

Derivatization of α-aminoacids, α-aminoesters and α-aminolactones as N-acetyl derivatives allow the accurate NMR determination of the enantiomeric purity. In these conditions the major coordination site with a chiral shift reagent will correspond to the NMR observation site. Experimental factors leading to the highest ΔΔδ values are ascertained. No straightforward correlation with absolute configurations can be established.