Synthesis and Antiviral Activity of the Carbocyclic Analogues of 5-Ethyl-2'-deoxyuridine and of 5-Ethynyl-2'-deoxyuridine

Article abstract of DOI:10.1021/jm00151a013

The carbocyclic analogue of the antiviral agent 5-ethyl-2'-deoxyuridine (EDU) was synthesized by two routes.The pivotal step in the first route is the reaction of lithium dimethylcuprate with the carbocyclic analogue of 5-(bromomethyl)-2'-deoxyuridine dib