Synthesis of alkyl-substituted arecoline derivatives as γ-aminobutyric acid uptake inhibitors

Article abstract of DOI:10.1021/jm00151a020

A series of N-methyltetrahydropyridine-3-carboxylic acids and methyl esters have been synthesized and biologically evaluated. Arecoline (6) was lithiated with LDA in THF to give 7, which was treated with various alkyl halides to afford exclusively the α-s