Nucleosides. 136. Synthesis and antiviral effects of several 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-alkyluracils. Some structure-activity relationships

Article abstract of DOI:10.1021/jm00151a025

In order to study structure-activity relationships between antiherpetic activity and the size of the C-5 alkyl substituents of 2'-fluoro-ara-U derivatives, six new nucleosides (1c-h) were synthesized. The 5-allyl analogue 1c was prepared by a Pd(II)-catal