Journal of Medicinal Chemistry p. 630 - 636 (1988)
Update date:2022-08-03
Topics:
Carson
Almond
Brannan
Carmosin
Flaim
Gill
Gleason
Keely
Ludovici
Pitis
Rebarchak
Villani
A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the 'Langendorff' guinea pig heart in vitro. They have been shown to exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines.
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