SYNTHESIS OF (+)-(3S,6S,10S,13S,17S,20S,24S,27S)-1,8,15,22-TETRAZA-3,6;10,13;17,20;24,27-TETRAEPOXYCYCLOOCTACOSANE. AN ENANTIOMERICALLY PURE TETRAAZACROWN ETHER WITH D4 SYMMETRY AND OF KNOWN ABSOLUTE CONFIGURATION.

Article abstract of DOI:10.1246/cl.1985.615

The title azacrown ether, which was synthesized using (+)-(2S,5S)-trans-2,5-bis(aminomethyl)tetrahydrofuran and (+)-(2S,5S)-trans-2,5-bis(hydroxymethyl)tetrahydrofuran as the C2 building blocks, is the first optically active organic molecule of D₄ symmetry with known absolute configuration.